SIRT1 is a central mediator in response to food deprivation.

A study published in the newest edition of the Journal of Neuroscience [July 28, 2010, 30(30):10220-10232] provides further evidence that SIRT1 plays a significant role in the physiological response to fasting in mice.  Imai and colleagues have found a link between neural activation and SIRT1 protein levels in the dorsomedial and lateral hypothalamic region of the brain. SIRT1 enhances expression of the Ox2r gene in this region, influencing production of ghrelin, physical activity and body temperature in the absence of food. The authors suggest that this provides evidence that SIRT1 is a key mediator in the physiological response to dietary restriction.